Keep Current with the Latest in Cell Biology Research

Multiomic Quantification of the KRAS Mutation Dosage Improves the Preoperative Prediction of Survival and Recurrence in Patients with Pancreatic Ductal Adenocarcinoma

[Experimental & Molecular Medicine] Scientists evaluated the prognostic value of the dosage of the KRAS G12 mutation, a key PDAC variant, and investigated the biological mechanism of the prognosis associated with the dosage of the KRAS G12 mutation.

The Frontiers of Knowledge Award Goes to the Researchers Who Laid the Biological Foundations for Revolutionary New Treatments in Diabetes and Obesity

[BBVA Foundation] The BBVA Foundation has honored four researchers with the Frontiers of Knowledge Award for their groundbreaking work in establishing the biological foundations for a new class of drugs. These drugs are highly effective in treating type 2 diabetes, promoting significant weight loss in obese individuals, and reducing their risk of cardiovascular issues.

Anti-PD-1 Exacerbates Bleomycin-Induced Lung Injury in Mice via Caspase-3/GSDME-Mediated Pyroptosis

[Cell Death & Disease] Researchers used a mouse model of lung injury induced by bleomycin (BLM) and then administered anti-programmed cell death 1 (aPD-1) antibodies to induce ICI-related lung injury. Compared with the BLM group, the aPD-1 + BLM group presented greater levels of lung inflammation and fibrosis, and decreased lung function.

Neoadjuvant Nivolumab Plus Ipilimumab Versus Chemotherapy in Resectable Lung Cancer

[Journal of Clinical Oncology] Adults with stage IB-IIIA resectable NSCLC received three cycles of nivolumab once every two weeks plus one cycle of ipilimumab or three cycles of chemotherapy followed by surgery.

Brain Aging and Rejuvenation at Single-Cell Resolution

[Neuron] Researchers review insights gleaned from single-cell omics studies of brain aging, starting with a cell-type-centric overview of age-associated changes and followed by a discussion of cell-cell interactions during aging.

Mapping the Developmental Trajectory of Human Astrocytes Reveals Divergence in Glioblastoma

[Nature Cell Biology] Researchers delineated the course of human astrocyte maturation to uncover discrete developmental stages and attributes mirrored by glioblastoma. They generated a transcriptomic and epigenomic map of human astrocyte maturation using cortical organoids maintained in culture for nearly two years.

Comprehensive Characterization of the Transcriptional Landscape in Alzheimer’s Disease (AD) Brains

[Science Advances] Scientists comprehensively characterized the landscape of noncoding RNAs (ncRNAs) and posttranscriptional modification (PTM) events in 1460 samples across six brain regions. They additionally identified 25,351 aberrantly expressed ncRNAs and altered PTM events associated with AD traits.

Selenoprotein-Mediated Redox Regulation Shapes the Cell Fate of HSCs and Mature Lineages

[Blood] Researchers employed a tRNASec gene knockout mouse model to simulate disrupted selenoprotein synthesis. This revealed insights into the protective roles of selenoproteins in preserving HSC stemness and B-lineage maturation, despite negligible effects on myeloid cells.

Measurable Residual Disease and Posttransplantation Gilteritinib Maintenance for Patients with FLT3-ITD-Mutated AML

[Blood] BMT CTN 1506 was a randomized Phase III study of gilteritinib compared to placebo as maintenance therapy after hematopoietic stem cell transplantation for patients with FLT3-ITD-mutated AML.

Targeting the CD74 Signaling Axis Suppresses Inflammation and Rescues Defective Hematopoiesis in RUNX1-Familial Platelet Disorder

[Science Translational Medicine] Single-cell RNA sequencing combined with functional analysis of samples from patients with RUNX1-familial platelet disorder (FPD) revealed that FPD hematopoietic stem and progenitor cells displayed increased myeloid differentiation and suppressed megakaryopoiesis because of increased activation of prosurvival and inflammatory pathways.

Donkey-Hide Gelatin-Derived Carbon Dots Activate Erythropoiesis and Eliminate Oxidative Stress for Aplastic Anemia Treatment

[ACS Nano] Researchers reported donkey-hide gelatin-derived carbon dots (G-CDs) that enabled erythropoiesis activation and oxidative stress elimination to tackle refractory aplastic anemia. G-CDs promoted the proliferation and erythroid differentiation of hematopoietic stem cells as well as erythrocyte maturation, activating the whole process of erythropoiesis.

Suppression of Thrombospondin-1–Mediated Inflammaging Prolongs Hematopoietic Health Span

[Science Immunology] Scientists identified thrombospondin-1 (Thbs1) as an essential regulator of inflammaging within HSCs. They described a transcriptomics-based approach for measuring inflammaging within stem cells and demonstrated that deletion of Thbs1 was sufficient to prevent HSC inflammaging.

Stay up-to-date with your field!

Subscribe for free weekly science newsletters.

spot_img